Abstract
A polyhydroxylated cyclic 13-membered sulfoxide (1) was isolated from an aqueous extract of Kothala-himbutu ( Salacia reticulata WIGHT). The structure of compound 1 was elucidated by 1D and 2D NMR and APCI-MS methods. The alpha-glucosidase inhibitory activity of compound 1 (IC 50: maltase, 0.227 microM; sucrase, 0.186 microM; isomaltase, 0.099 microM) was much greater than the inhibitory activity of salacinol and kotalanol, which were previously isolated from Kothala-himbutu.
MeSH terms
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Animals
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Glycoside Hydrolase Inhibitors*
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Heterocyclic Compounds, 1-Ring / chemistry
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Heterocyclic Compounds, 1-Ring / isolation & purification*
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Heterocyclic Compounds, 1-Ring / pharmacology*
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Intestine, Small / enzymology
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Molecular Structure
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Monosaccharides / chemistry
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Monosaccharides / isolation & purification
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Pancreas / enzymology
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Plants, Medicinal / chemistry*
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Rats
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Salacia / chemistry*
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Sri Lanka
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Sucrase / drug effects
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Sugar Alcohols / chemistry
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Sugar Alcohols / isolation & purification
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Sulfates / chemistry
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Sulfates / isolation & purification
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Sulfur Compounds / chemistry
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Sulfur Compounds / isolation & purification*
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Sulfur Compounds / pharmacology*
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Swine
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alpha-Amylases / antagonists & inhibitors
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alpha-Glucosidases / drug effects
Substances
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Glycoside Hydrolase Inhibitors
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Heterocyclic Compounds, 1-Ring
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Kotalanol
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Monosaccharides
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Sugar Alcohols
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Sulfates
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Sulfur Compounds
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salacinol
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alpha-Amylases
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alpha-Glucosidases
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Sucrase